By Robert A. Goodnow Jr.
This ebook comprehensively describes the advance and perform of DNA-encoded library synthesis expertise. jointly, the chapters aspect an method of drug discovery that provides an enticing addition to the portfolio of present hit iteration applied sciences equivalent to high-throughput screening, structure-based drug discovery and fragment-based screening. The book:
- Provides a worthwhile advisor for knowing and employing DNA-encoded combinatorial chemistry
- Helps chemists generate and display novel chemical libraries of huge dimension and caliber
- Bridges interdisciplinary parts of DNA-encoded combinatorial chemistry – artificial and analytical chemistry, molecular biology, informatics, and biochemistry
- Shows medicinal and pharmaceutical chemists the best way to successfully increase on hand “chemical house” for drug discovery
- Provides professional and updated precis of stated literature for DNA-encoded and DNA-directed chemistry know-how and methods
Read Online or Download A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug Discovery PDF
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Additional info for A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug Discovery
Sample text
3. The specific sequence of the bases in DNA, or the order in which they are connected, encodes genetic information. DNA forms a double helix, meaning that two polynucleotide chains are twisted together around an axis, forming a double-helical structure. These two chains, also called strands, run antiparallel to each other: one strand running from 5′- to 3′-end and the other one from 3′- to 5′-end. The bases, due to their hydrophobicity, are stacked inside a helix and perpendicular to its axis, while the backbone that contains alternating 2-deoxy-d-ribose and phosphate moieties is located on the outside of the helix.
Simons, J. , Simpson, J. , Tartaro, K. , Vogt, K. , Volkmer, G. , Wang, S. , Weiner, M. , Begley, R. , Rothberg, J. M. (2005). Genome sequencing in microfabricated high-density picolitre reactors. Nature, 437, 376–380. 31. , Kinzler, K. , Vogelstein, B. (2003). Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations. Proc. Natl. Acad. Sci. , 100, 8817–8822. 32. , Nyren, P. (1998). A sequencing method based on real-time pyrophosphate.
Fenn, J. , Meng, C. , Wong, S. , Whitehouse, C. M. (1989). Electrospray ionization for mass spectrometry of large biomolecules. Science, 246, 64–71. 15. , Chakel, J. , Hancock, W. S. (1997). Analysis of oligonucleotides by HPLC-electrospray ionization mass spectrometry. Anal. , 69, 1320–1325. 16. , Bischoff, R. (1994). Negative electrospray ionization mass spectrometry of synthetic and chemically modified oligonucleotides. , 22, 3895–3903. 17. , Giesmann, U. (1991). Matrix-assisted laser desorption ionization mass spectrometry.
