By John A. Borrelli, Ylenia D. Giannini
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Extra resources for Advances in Viral Genomes Research
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Both studies showed that the injection of SHPZ, but not of a control vector only expressing the reporter gene lacZ, attenuated neuropathic pain and reduced induced hypersensitivity in rats [21, 157]. Acknowledgments ALE and DAJ would like to thank the French CNRS and the Argentinean CONICET institutions for supporting the International Associated Laboratory (LIA) DEVENIR. Part of this work was supported by Association Française contre les Myopathies (AFM). MEM PhD studies were supported by AFM.
An amplicon encoding wt-CREB was used to show that increasing CREB in the auditory thalamus enhanced memory and generalization of auditory conditioned fear, indicating that CREB-mediated plasticity in the thalamus plays a role in this cognitive process [80]. Using an amplicon vector encoding a dominant-negative mutant form of CREB (mCREB), Brightwell and collaborators demonstrated that hippocampal overexpression of mCREB can block long-term – though not short-term – memory for a socially transmitted food preference, therefore involving hippocampal CREB function in this type of memory [81].
Lehman, Herpes simplex virus DNA replication. Annu Rev Biochem, 1997. 66: p. 347-84. [36] Cunningham, C. J. Davison, A cosmid-based system for constructing mutants of herpes simplex virus type 1. Virology, 1993. 197(1): p. 116-24. , Helper virus-free transfer of herpes simplex virus type 1 plasmid vectors into neural cells. J Virol, 1996. 70(10): p. 7190-7. , Construction of HSV-1 BACs and their use for packaging of HSV-1-based amplicon vectors. Methods Mol Biol, 2004. 256: p. 241-56. O. A. Chiocca, Improved HSV-1 amplicon packaging system using ICP27-deleted, oversized HSV-1 BAC DNA.
