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However, a number of critical paracrine signals and transcription factors have been identified. These include the transcription factors Runx2 and osterix, which when absent prevent OB formation, and members of the bone morphogenetic protein (BMP) family (5–7), which initiate the signals for OB differentiation. Most recently, it was demonstrated that Wnt signaling pathways are involved in the decision of the mesenchymal progenitor cell to become either an adipocyte or an OB (8–12). As matrix calcifies under the influence of the OB-produced enzyme bone-specific alkaline phosphatase, a portion of the OBs are entrapped in the calcified matrix and persist in bone as unique cells called osteocytes.
Specific recognition of human CD3-CD16+ natural killer cells requires the expression of an autosomic recessive gene on target cells. J. Exp. Med. 172:47–52 79. Ciccone E, Colonna M, Viale O, Pende D, Di Donato C, et al. 1990. Susceptibility or resistance to lysis by alloreactive natural killer cells is governed by a gene in the human major histocompatibility complex between BF and HLA-B. Proc. Natl. Acad. Sci. USA 87:9794–97 (and correction in Proc. Natl. Acad. USA 88:5477) 80. Ciccone E, Pende D, Viale O, Di Donato C, Tripodi G, et al.
J. Immunol. 129:2001–3 103. Kohler G, Milstein C. 1975. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256:495–97 Annu. Rev. Immunol. 24:1-31. org by HINARI on 08/26/07. For personal use only. ANRV270-IY24-01 30 Strominger Annu. Rev. Immunol. 24:1-31. org by HINARI on 08/26/07. For personal use only. ANRV270-IY24-01 ARI 13 February 2006 11:14 104. Herzenberg LA, Herzenberg LA. 2004. Genetics, FACS, immunology, and redox: a tale of two lives intertwined. Annu.
