By Anthony S. Fauci, R. Ballieux
398 pages
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Extra info for Antibody Production in Man: In Vitro Synthesis and Clinical Implications
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Immunol. , J. Immunol. 425 (1977). 103, 32 (1969). Sultzer, B. , Nature New Biol. Watson, J. , J. Exp. Med. 140, 240, 198 (1972). 1147 (1974). This page intentionally left blank Antibody Production in Man CHAPTER 4 THE PLAQUE-FORMING CELL RESPONSE OF HUMAN BLOOD LYMPHOCYTES COCULTIVATION OF LYMPHOCYTES FROM DIFFERENT INDIVIDUALS1 Marc E. Wekslerz Abby Schwartz Jay Blum Young Tai Kim The Department of Medicine Cornell University Medical College New York, New York I. INTRODUCTION Lymphocytes can be divided into two major classes: T-lymphocytes and B-lymphocytes.
Recent studies by Andersson et al. (1977) have demonstrated that of all splenic mouse B lymphocytes, 30% respond to the PBA properties of lipopolysaccharide (LPS). This finding substantiates the notion that not all B cells are equipped with receptors for all PBA substances. This finding allows the use of distinct PBA substances for the delineation of B cells of different subsets, and therefore, functional markers for subpopulations might be as useful as cell surface markers for the definition of abberant cell subpopulations.
I , 1014, 1978. Bernier, G. , Gunderman, J. R. , and Ruymann, F. , Blood 40, 795. 32. Zegers, B. J. , Mul, N. A. , Stoop, J. , Vossen, J. , and Ballieux, R. , N. Engl. J. Med. 294, 1026 (1976). 33. , and Oberdorfer, A. Blood 47, 79 (1976). 34. Lawton, A. R. , Wu, L. Y. , and Cooper, M. , in "Immunodeficiency in Man and Animals" (D. ), p. 28. Sinauer Associates, Sunderland, Massachusetts (1975). 35. Yount, W. , and Kunkel, H. G. , J. Clin. Invest. 49, 1957 (1970). M. D. Cooper et al. Kearney, J.
