By William T. Jackson, Michele Swanson

Autophagy, an infection, and the Immune Response provides a unified assessment of the jobs of mobile autophagy in the course of microbial infection.

Introductory chapters ground the reader by way of laying out the autophagic pathway from a mobile perspective, and directory assays on hand for measuring autophagy. next chapters address virus interactions with autophagy equipment, a few of the roles of autophagy parasitic an infection, and interactions of micro organism with the autophagic pathway. Concluding chapters explore the relationships of autophagy to systemic immune responses, together with antigen presentation, ER tension, and creation of IFN-gamma.

Designed as a source for these attracted to beginning studies on the connection among autophagy and an infection or immunity, the book combines sensible state-of the artwork method descriptions with an summary of the wide range of recognized interactions among pathogens and the autophagic pathway.

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13, 119–120. H. (2009). The adaptor protein p62/SQSTM1 targets invading bacteria to the autophagy pathway. J. Immunol. 183, 5909–5916. , and Zhang, H. (2012) Autophagy in immunity: implications in etiology of autoimmune/ autoinflammatory diseases. Autophagy 8, 1286–1299. 1 INTRODUCTION Autophagy is essential for intracellular clearance of cytosol, organella, bacteria, viruses, and scrapie prion protein. In addition, aberrant autophagy is associated with neurodegenerative diseases, cardiomyopathy, tumorigenesis, diabetes, fatty liver, Crohn’s disease, and more (Mizushima and Komatsu, 2011; Tanida, 2011).

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J. (1995) Isolation and characterization of yeast mutants in the cytoplasm to vacuole protein targeting pathway. J. Cell Biol. 131, 591–602. , et al. (2009) Nutrient-dependent mTORC1 association with the ULK1–Atg13–FIP200 complex required for autophagy. Mol. Biol. Cell 20, 1981–1991. , et al. (2000) A ubiquitin-like system mediates protein lipidation. Nature 408, 488–492. , and Hugues, S. (2010) MHC class II-restricted antigen presentation by plasmacytoid dendritic cells inhibits T cell-mediated autoimmunity.

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