The 4 quantity Encyclopedia of an infection and Immunity Vaccines covers all autoimmune, tropical, and infectious illnesses. It additionally locations emphasis on genetics, body structure, metabolism, pathogenesis and utilized microbiology.
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Additional resources for Encyclopedia of Medical Immunology: Autoimmune Diseases
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2000;191:1269–80. Adaptive Immune Cells in the Liver Manigold T, Racanelli V. T-cell regulation by CD4 regulatory T cells during hepatitis B and C virus infections: facts and controversies. Lancet Infect Dis. 2007;7:804–13. Peppa D, Micco L, Javaid A, Kennedy PT, Schurich A, Dunn C, Pallant C, Ellis G, Khanna P, Dusheiko G, et al. Blockade of immunosuppressive cytokines restores NK cell antiviral function in chronic hepatitis B virus infection. PLoS Pathog. 2010;6:e1001227. Rehermann B, Nascimbeni M.
2005;5:215–29. Thimme R, Wieland S, Steiger C, Ghrayeb J, Reimann KA, Purcell RH, Chisari FV. CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection. J Virol. 2003;77:68–76. Webster GJ, Reignat S, Brown D, Ogg GS, Jones L, Seneviratne SL, Williams R, Dusheiko G, Bertoletti A. Longitudinal analysis of CD8+ T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: implications for immunotherapy.
These findings might help in the development of future immunomodulatory therapies. 5 A The drivers contributing to the changes in phenotype and functional impairment of HBVspecific T cells are thought to be manifold. Firstly, the liver environment in which HBV-specific T cells are likely to encounter their cognate antigen has been described to be immunosuppressive, with low levels of arginine and high levels of the immunosuppressive cytokines IL-10 and TGF-b. Resident hepatic APC, such as liver sinusoidal endothelial cells (LSEC), have been shown to actively induce tolerance in antigen-specific T cells.
